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Program

08:30 – 09:00 h		Registration
09:00 – 09:30 h	Plenary	Plenary Lecture 2: Cancer immunotherapy Chair: Daniel Speiser, (Lausanne, CH)
		T cell receptor gene therapy Thomas Blankenstein, (Berlin, D)
09:30 – 10:00 h	Foyer Lichthof (Exhibition)	Coffee break
10:00 – 11:30 h		Symposia 3 a–c
10:00 – 11:30 h	Plenary	Symposium 3a: Clinical Immunology Vaccination Chair: Martin Bachmann, (Bern, CH) / Steve Pascolo, (Zurich, CH)
		Preclinical development of vaccine candidates against COVID-19 Martin Bachmann, (Bern, CH)
		YF17D-based vaccines against COVID-19 and other emerging infections Kai Dallmeier, (Leuven, BE)
		Abstract Talk (OP2) HLA-DRB1*04 associated chronic inflammation and extracellular matrix-specific autoimmunity following inadvertent periarticular influenza vaccination Julia R. Hirsiger, (Basel CH)
		Abstract Talk (OP24) PD-L1 Incorporation within HIV Virions Contribute to Functionally Impair T-Follicular Helper Cells Olivia Munoz, (Lausanne CH)
10:00 – 11:30 h	Symposia room 1	Symposium 3b: Clinical Immunology Lindenmann symposium for innate immunity Chair: Otto Haller, (Zurich, CH) / Stéphanie Hugues, (Geneva, CH)
		NK cell-mediated recognition of virus-infected cells Marcus Altfeld, (Hamburg, D)
		Stroma-macrophage interactions Marc Bajénoff, (Marseille, F)
		Abstract Talk (OP8) Autophagy proteins in the restriction of Kaposi’s Sarcoma-Associated Herpesvirus Entry Katarina Schmidt, (Zurich CH)
		Abstract Talk (OP18) Multisystem Inflammation and Susceptibility to Viral infections in Human ZNFX1 Deficiency Stefano Vavassori, (Zurich CH)
10:00 – 11:30 h	Symposia room 2	Symposium 3c: Clinical Immunology Novel biologics in immunotherapy Chair: Thomas Hauser, (Zurich, CH) / Onur Boyman, (Zurich, CH)
		Mitochondria dynamics tailor T cell anti-tumor immunity Ping-Chih Ho, (Lausanne, CH)
		Immunotherapy with Gene Engineered T Cells Hans Stauss, (London, UK)
		Abstract Talk (OP1) Development of a compartment locked IL-12 version with increased tissue retention and minimal peripheral exposure for local glioblastoma therapy Linda Schellhammer, (Schlieren CH)
		Abstract Talk (OP6) Anti-CD20 rituximab IgG1, IgG3 and IgG4 but not IgG2 subclass differentially trigger Ca2+ mobilization and cytotoxicity in human NK cells Marta Freitas Monteiro, (Geneva CH)
11:30 – 13:15 h	Foyer Lichthof (Exhibition)	Lunch break with industry exhibit
12:15 – 13:00 h	Symposia room 1	Company Symposium Sponsored by Novartis Pharma Schweiz AG
		Familial mediterranean fever (FMF) - behind the scene More than just fever: diagnosis and standard treatment of FMF / How to treat patients with FMF and amyloidosis Dr. med. Tatjana Welzel, University Children's Hospital Basel (UKBB), Switzerland / Prof. Dr. med. Norbert Blank, University Hospital Heidelberg, Germany
13:15 – 14:45 h		Symposia 4 a–c
13:15 – 14:45 h	Plenary	Symposium 4a: Basic Immunology Zinkernagel symposium on anti-viral immunology Chair: Manfred Kopf, (Zurich, CH) / Annette Oxenius, (Zurich, CH)
		Mechanisms of CD8 T cell immunity and pathology Dietmar Zehn, (Freising, D)
		Functional biology of hepatic CD8+ T cells Matteo Iannacone, (Milan, I)
		Abstract Talk (OP13) Human tissue resident memory T cells arise during Epstein Barr virus infection in a humanized mouse model Daniel Kirchmeier, (Zurich CH)
		Abstract Talk (OP15) Viral Infections License CD4+ T Cells for Antigen‐Independent Recruitment and Activation Nima Yassini, (Zurich CH)
13:15 – 14:45 h	Symposia room 1	Symposium 4b: Basic Immunology Tumor immunology Chair: Pedro Romero, (Lausanne, CH) / Mitchell Levesque, (Zurich, CH)
		Targeting Regulatory T Cells in Cancer: Means and Mechanism Sergio Quezada, (London, UK)
		Immunoregulation and the tumor microenvironment Pamela Ohashi, (Toronto, CA)
		Abstract Talk (OP20) Isocitrate dehydrogenase 2 inhibition induces memory CD8+ T cells with enhanced antitumor function Alison Jaccard, (Epalinges CH)
		Abstract Talk (OP21) Bedside formulation of a personalized multi-neoantigen vaccine against mammary carcinoma Mona Mohsen, (Bern CH)
13:15 – 14:45 h	Symposia room 2	Symposium 4c: Clinical Immunology Microbiota Chair: Wolf-Dietrich Hardt, (Zurich, CH) / Emma Slack, (Zurich, CH)
		The diversity and specialty of intestine mucosal antibody responses Andrew Macpherson, (Berne, CH)
		Gut microbiota mediated regulation of neuroinflammation Gurumoorthy Krishnamoorthy, (Martinsried, D)
		Abstract Talk (OP12) Epithelium-autonomous NAIP/NLRC4 prevents TNF-driven inflammatory destruction of the gut epithelial barrier in Salmonella-infected mice Stefan Fattinger, (Zurich CH)
		Abstract Talk (OP19) Aryl hydrocarbon receptor (AhR) signaling in the host response directed against the skin commensal yeast Malassezia during health and disease Eduardo Gushiken Ibañez, (Zurich CH)
14:45 – 15:15 h	Foyer Lichthof (Exhibition)	Coffee break
15:15 – 16:15 h	Lichthof Gallery	Poster session with presenters present at odd numbered posters
16:15 – 17:00 h	Plenary	Plenary Lecture 3: Anti-viral Immunity Chair: Christian Münz, (Zurich, CH)
		Antibody-mediated neutralization of SARS-CoV-2 Florian Klein, (Cologne, D)
Ab 17:00 h	Plenary	Closing & Award Ceremony Awarding of the Brunello Wüthrich Poster Prices, the Biotest Poster Prices and the ACTERIA Oral Prices Christian Münz, (Zurich, CH)

Program

Registration

Plenary Lecture 2: Cancer immunotherapy

T cell receptor gene therapy

Coffee break

Symposia 3 a–c

Symposium 3a: Clinical Immunology

Vaccination

Preclinical development of vaccine candidates against COVID-19

YF17D-based vaccines against COVID-19 and other emerging infections

Abstract Talk (OP2)HLA-DRB1*04 associated chronic inflammation and extracellular matrix-specific autoimmunity following inadvertent periarticular influenza vaccination

Abstract Talk (OP24)PD-L1 Incorporation within HIV Virions Contribute to Functionally Impair T-Follicular Helper Cells

Symposium 3b: Clinical Immunology

Lindenmann symposium for innate immunity

NK cell-mediated recognition of virus-infected cells

Stroma-macrophage interactions

Abstract Talk (OP8)Autophagy proteins in the restriction of Kaposi’s Sarcoma-Associated Herpesvirus Entry

Abstract Talk (OP18)Multisystem Inflammation and Susceptibility to Viral infections in Human ZNFX1 Deficiency

Symposium 3c: Clinical Immunology

Novel biologics in immunotherapy

Mitochondria dynamics tailor T cell anti-tumor immunity

Immunotherapy with Gene Engineered T Cells

Abstract Talk (OP1)Development of a compartment locked IL-12 version with increased tissue retention and minimal peripheral exposure for local glioblastoma therapy

Abstract Talk (OP6)Anti-CD20 rituximab IgG1, IgG3 and IgG4 but not IgG2 subclass differentially trigger Ca2+ mobilization and cytotoxicity in human NK cells

Lunch break with industry exhibit

Company Symposium

Familial mediterranean fever (FMF) - behind the sceneMore than just fever: diagnosis and standard treatment of FMF / How to treat patients with FMF and amyloidosis

Symposia 4 a–c

Symposium 4a: Basic Immunology

Zinkernagel symposium on anti-viral immunology

Mechanisms of CD8 T cell immunity and pathology

Functional biology of hepatic CD8+ T cells

Abstract Talk (OP13)Human tissue resident memory T cells arise during Epstein Barr virus infection in a humanized mouse model

Abstract Talk (OP15)Viral Infections License CD4+ T Cells for Antigen‐Independent Recruitment and Activation

Symposium 4b: Basic Immunology

Tumor immunology

Targeting Regulatory T Cells in Cancer: Means and Mechanism

Immunoregulation and the tumor microenvironment

Abstract Talk (OP20)Isocitrate dehydrogenase 2 inhibition induces memory CD8+ T cells with enhanced antitumor function

Abstract Talk (OP21)Bedside formulation of a personalized multi-neoantigen vaccine against mammary carcinoma

Symposium 4c: Clinical Immunology

Microbiota

The diversity and specialty of intestine mucosal antibody responses

Gut microbiota mediated regulation of neuroinflammation

Abstract Talk (OP12)Epithelium-autonomous NAIP/NLRC4 prevents TNF-driven inflammatory destruction of the gut epithelial barrier in Salmonella-infected mice

Abstract Talk (OP19)Aryl hydrocarbon receptor (AhR) signaling in the host response directed against the skin commensal yeast Malassezia during health and disease

Coffee break

Poster session with presenters present at odd numbered posters

Plenary Lecture 3: Anti-viral Immunity

Antibody-mediated neutralization of SARS-CoV-2

Closing & Award Ceremony

Awarding of the Brunello Wüthrich Poster Prices, the Biotest Poster Prices and the ACTERIA Oral Prices

Abstract Talk (OP2)
HLA-DRB1*04 associated chronic inflammation and extracellular matrix-specific autoimmunity following inadvertent periarticular influenza vaccination

Abstract Talk (OP24)
PD-L1 Incorporation within HIV Virions Contribute to Functionally Impair T-Follicular Helper Cells

Abstract Talk (OP8)
Autophagy proteins in the restriction of Kaposi’s Sarcoma-Associated Herpesvirus Entry

Abstract Talk (OP18)
Multisystem Inflammation and Susceptibility to Viral infections in Human ZNFX1 Deficiency

Abstract Talk (OP1)
Development of a compartment locked IL-12 version with increased tissue retention and minimal peripheral exposure for local glioblastoma therapy

Abstract Talk (OP6)
Anti-CD20 rituximab IgG1, IgG3 and IgG4 but not IgG2 subclass differentially trigger Ca2+ mobilization and cytotoxicity in human NK cells

Familial mediterranean fever (FMF) - behind the scene
More than just fever: diagnosis and standard treatment of FMF / How to treat patients with FMF and amyloidosis

Abstract Talk (OP13)
Human tissue resident memory T cells arise during Epstein Barr virus infection in a humanized mouse model

Abstract Talk (OP15)
Viral Infections License CD4+ T Cells for Antigen‐Independent Recruitment and Activation

Abstract Talk (OP20)
Isocitrate dehydrogenase 2 inhibition induces memory CD8+ T cells with enhanced antitumor function

Abstract Talk (OP21)
Bedside formulation of a personalized multi-neoantigen vaccine against mammary carcinoma

Abstract Talk (OP12)
Epithelium-autonomous NAIP/NLRC4 prevents TNF-driven inflammatory destruction of the gut epithelial barrier in Salmonella-infected mice

Abstract Talk (OP19)
Aryl hydrocarbon receptor (AhR) signaling in the host response directed against the skin commensal yeast Malassezia during health and disease